Thursday, July 30, 2020

Systemic racism

On July 28, 2020 Bill Barr dismissed during a House hearing that there is systemic racism in the US.  He is not alone.  Trump and many others have said such.

That systemic racism exists in the US is undeniable.  Blacks have a life expectancy ~ 3 years shorter than the White.  Blacks are also poorer.  Unless there is anything in their DNA or a darker skin that explains the deficits (no study has said so, and no scientists can reasonably claim so), the only remaining explanation is the environment, with systemic racism being a big part of it.  There is a slight complication in the case of native Americans, who also suffer from racism.  Many native American live on barren lands separate from most of the country’s population for centuries.  But black people have lived in the same rural and urban areas with others for over 100 years.  There are “good” vs “bad” neighborhoods in the cities, but they are the consequence rather than the cause of black poverty.  If two peoples have lived together for a long time, and DNA can’t explain the differences, what else can?  Only the history of environments can, and everybody knows the history.

Systemic racism manifests itself wherever one looks in the society: per capita, Blacks are more likely to die than Whites.  At the workplace.  At the hospitals.  On the streets.  Etc.  So what the police are complaining has merits, because they have to deal with the societal, systemic racism in the most direct and violet manner on a daily basis, and they can’t solve the racism problem, but they are getting the most and visible blame.  It is a sound explanation but not a valid excuse, given what they do also contributes to the problem.  
  
The BLM movement started in 2014, and its national support level reached solidly over 50% only after George Floyd’s death in May 2020.  A large portion of the US population are still in denial, and Trump is clinging to that.  Trump being what he is, only the worst possible people are willing to work for him.  Barr is the personal lawyer and firewall for Trump.  The lying of Mike Pompeo is second only to Trump’s.  Peter Navarro is the most ignorant PhD, as fact-free and logic-free as Steven Bannon.  Stephen Miller and Kellyanne Conway are among the few people sticking to Trump since the beginning, yet even their families are against them and Trump.  Not to mention Mary Trump, and other members of his extended families whose silence means only one thing.  Still, what will come out of BLM, other than superficial things like statue and flag removal, remains to be seen, because many more people, not just those in the right, have benefited from the current system.   

Monday, July 20, 2020

SARS’ fingerprints on COVID-19 pandemic

My 7/18/2020 blog first wondered what explains the differences in SARS and COVID-19 consequences, and how the global responses have been guided or affected by the previous SARS experience.  The second question, in particular, had not been asked before.

For background, both SARS and COVID-19 are caused by CoVs, 80% identical, with similar transmission mechanisms and symptoms.  SARS has a higher fatality rate (10%) than COVID-19 (<1%).  SARS is a faster onset and more severe disease, while COVID-19 is more sneaky, producing many pre-symptomatic patients who are infectious.  Between SARS and COVID-19 there was MERS, which impacted primarily the Middle East and South Korea, and was by all accounts like SARS.  Before SARS there were also several CoVs known to cause mild cold/flu like symptoms.   

The contrast in SARS and COVID-19 outcomes couldn’t have been starker.  SARS led to “merely” 8K infections and 800 deaths around the world, with the most cases and 400 deaths in China.  Guangdong had the first known SARS case in Nov 2002.  For months it went under the radar, with a cause unknown until well into 2003.  Only when SARS caused local transmission in Beijing hospitals in Feb and March 2003 did the Chinese government acted.  Even then, neither Guangdong nor Beijing was locked down, and most people didn’t wear a mask.  Once SARS was over in June 2003, it was considered too deadly, even though cold/flu kills far more people each year.  Well, nobody has seen nothing yet.

Here lie the questions: Why was SARS a smaller outbreak than COVID-19?  Why didn’t SARS infect more people when nobody paid attention for months, when SARS and COVID-19 are on the surface similarly contagious?  Can the differences in symptom onsets and severity, which likely means that COVID-19 carriers were harder to identify, adequately explain why the COVID-19 pandemic was so much worse?  At this moment there are no studies analyzing and quantifying these questions.  May also involve some pure chance or good/bad luck as well.  But I propose that our prior experience with SARS (and other CoVs) influenced our responses in 2020, likely can explain some of the early judgements and actions, and led in part to the current situation.

When the Wuhan doctor Zhang Jixian realized that the 7 patients she saw might have a new disease on Dec 26, 2019, she alerted the authority because of a connection to the Wuhan Huanan Seafood Market, as a disease jumping from animals to humans, like SARS, was suspected.  Still, how do you ascertain it is a new disease, especially when the symptoms are cold/flu like, in the midst of a high cold/flu season?  There are dozens of known pathogens that cause cold/flu, so one has to rule them out one by one, verify in multiple patients, not an easy task.  But by Jan 3, 2020 all the usual suspects were out, and it was indeed a new disease, so WHO officially notified.  Sequencing was performed, coupled with a novel CoV isolation on Jan 7.  On Jan 11 the new CoV and genome was announced (the first sequence was uploaded on Jan 5).  Compared with SARS, which took months.  So far so good.

Now the prior experience with SARS set in further.  It is a CoV, so likely human-to-human transmission, but of the close contacts of the first generation patients, few had showed any symptoms.  If it was like SARS, why hadn’t we seen more sickness earlier?  But if not, why were the enrolled patients as sick as SARS?  These questions must have vexed the doctors in Wuhan and the first two teams of experts sent by Beijing.  

This was the backdrop of the fateful statements by the experts on Jan 14 that human-to-human transmission can’t be ruled out or may be limited.  In hindsight, mid Jan was the time when the 2nd generation of COVID-19 transmission would start to get sick.  Moreover, being sick still doesn’t mean human-to-human transmission, as one could get the virus from the animals or meat brought home, another SARS lesson.  Test kits were being developed around this time, which would identify more patients, not just among the close contacts, and the most importantly, tell COVID-19 from other diseases.  Recognizing more patients finally allowed the 3rd team of experts to conclude human-to-human transmission on Jan 19.

By this early junction, one can see the SARS experience already made huge impacts.  The first is that by raising the awareness of a possible zoonotic jump it helped to identify a new disease, a positive.  The second is that by looking for quick and acute symptoms like in SARS, the possibility of presymptomatic and asymptomatic COVID-19 was not considered, a negative.  The third is that trying to rule in or out a zoonotic jump led to a dead end, and like the second point above, delayed the human-to-human transmission assessment, another negative.  Of course, presymptomatic and asymptomatic would be known soon afterwards, and without testing one can’t diagnose more infections, so it always takes time to gather evidence.  Crucially, the two negatives were well within the normal learning curve, while nothing followed without the first positive. 

Unlike SARS, when the Chinese government knew or did little for months, on Jan 23, 2020 Beijing ordered a Wuhan lockdown, determined to avoid the repeat of 2003.  Other measures soon enacted, and everybody wore a mask.  But because of the spread, fueled by the presymptomatic and asymptomatic, COVID-19 likely already infected thousands, including medical staff, in Wuhan by Jan 23.  

The goal now turned to treat the patients and stop the transmission, as in any infectious disease.   Hence the Chinese COVID-19 response was similar to the SARS response, only with effort 10x or more.  With the situation more serious than in 2003, medical staff around the country soon poured into Wuhan and Hubei, and two hospitals were built in about 10 days in Wuhan, with more buildings converted to shelter hospitals to treat and monitor the mild cases.  One thing different from SARS, though, is that the Chinese doctors and scientists this time contributed the most to the understanding of COVID-19.  Obviously the identification and sequencing of the virus within 2 weeks.  Then elucidating the transmission routes, symptoms, presymptomatic and asymptomatic carriers, who are susceptible and who are not, fatality, etc, by the end of Jan, and various treatment options during Feb.   
   
By early Feb COVID-19 in China was already worse than SARS globally.  By Feb 20, when COVID-19 was dying down, it was clearly the worst China has seen in living memories, but most people in the world would think we’d just survived a badder SARS, and that was it.  Yet how other countries had applied their SARS experience would show the results soon.

For every country, the only historic reference for COVID-19 was SARS (MERS lesser).  The following reasoning by the West and US was hard to fault.  China didn’t do much for a few months with SARS, and ended up with most of the SARS cases and half of the deaths in the world.  Chinese reported COVID-19 death rate lower than SARS.  China actually acted much faster in 2020.  So if the SARS precedent holds, other countries will do no worse than China.  And by banning Chinese entry, we would do even better than in 2003.

Many statements and (in)actions by the West from Jan to March can now be finally explained or understood in light of this logic.  Remember a lot of people were saying it was just a flu?  Getting it was no big deal?  Because it was a flu or SARS, masks were not needed, per Western traditions.  Since it would end up better than SARS, little preparation was needed.  And why miss a chance to bash China when you can?

Now the outcomes have been so dramatically different, what went bust?  The Chinese data are not wrong.  Their fatality rate is in line with rest of the world.  The critical scientific findings out of China have been confirmed time and time again by later studies from other countries.  Perhaps what the West missed was that, despite China’s drastic measures, COVID-19 still ended up inflicting a much heavier toll than SARS, indicating that COVID-19 is on a different level from SARS.  Cases are easy to miss, and superspreading can get out of control quickly.  These should have raised a big red flag early on for everybody, never a license for complacency.  Should have paid attention to what China did: lockdowns, masks, etc, rather than taking it as a fact-free article of faith that China always screws up (7/18/2020 blog).  If China did, did the West, with a 1-2 months’ head start, not? 

There are also countries that do well.  East and SE Asians started to wear masks quickly.  South Korea, experiencing MERS a few years back, planned for COVID-19.  Germany also had an early surveillance and testing program.  They were still hit harder than by SARS for a couple of reasons.  First is COVID-19 is just difficult to tame.  Second is bad luck, and once the virus has gone global and long-lasting, repeated importation and superspreading become unavoidable.  A superspreading event led to cascades of almost 10K cases in South Korea.  Japan was the most affected by cases from the US.  Germany was heavily impacted by its neighbors that didn’t prepare as well as Germany.     
     
Past experience plays an integral part in learning.  Undoubtedly the SARS saga in 2003 has greatly influenced the global COVID-19 responses, both positively and negatively.  Looking back 17 years ago is important, so is looking at two months ago, one month ago, or in real time.  At the end of the day, (mis)applying the SARS experience is only one of the many intertwined reasons that have got us here (7/18/2020 blog).         

Sunday, July 19, 2020

The career of Lin Dan


Lin Dan announced his retirement on July 4, 2020.  With so much going on in the world right now, one can still marvel at what a legendary player.  By 2010 LD had already been considered by fans and peers as the GOAT in badminton, and my 8/15/2011 blog laid out all the reasons.  In the end he won 2 Olympics Golds, 5 World Championships, 6 All England, 2 Asian Games singles, 6 Thomas Cups, 5 Sudirman Cups, and many other titles.  If any other player had won just half of these numbers in majors, he would enter the discussion of GOAT: no one has.  LD is like Federer and Nadal in tennis combined in badminton.  In addition, in almost all sports men’s competition is tougher than women’s, see tennis, yet no female badminton player has come close to LD’s title hauls.  LD is further the only male player ranked #1 in both the old 15-point and current 21-point scoring systems, maybe even the brief 7-point system, a curious record hard to break, although the 7-point history is difficult to check right now.

Only two players can be nominally compared to LD.  One is Yang Yang (8/15/2011 blog), whose career was too short (1985-1990).  The other is Rudy Hartono, the winner of 8 AE from the late 1960s to 1970s.  The issue is that Chinese were not playing in AE until 1980s.  According to “indirect” match results the top Chinese players then were at least as competitive as Rudy.  WC started only around 1980, and OG in 1992, so the earlier generations of players were at a disadvantage in terms of title opportunities.   

All good badminton players are unique in terms of playing styles.  But LD is the most spectacular one.  He is extremely explosive, yet also does finesse.  Up until the 2008 Olympics, LD’s style was fast and furious.  He could smash and kill from everywhere in the court, and dive, retrieve, and defend seemingly every attack.  After 2009 he toyed with more controls and shuttle movements, smashing less and less over time.  All players evolve, but being equally successful at different styles was unheard of.

The consistency of LD stands out.  None better illustrates this feature than his Thomas and Sudirman Cup records.  He was the first single in most of those 11 winning teams, so tasked with playing the first match against the best players in the opposing teams, and had to set the tone, in the semis and finals, at least in the Thomas Cup.  Stakes couldn’t be higher.  All told, LD lost his match only once, to LCW.  LD never lost a team event as the first single.  Of course, LD was helped by one of the best men’s doubles of all time, FHF/CY, and excellent singles BCL and Chen Jin.  It was an injured CJ who famously won the last point against Malaysia after LD lost to LCW, saving LD’s record. 
   
The only knock on LD is that he hanged on for too long, well past his prime.  We all wish for a perfect ending like Pete Sampras playing his final game by winning the US Open in 2003.  LD’s W-L records from 2015 or 2017 dragged down his career numbers unnecessarily.  LD signed a long-term contract with Yonex, so maybe he was just playing for money till the end?  But how long did LD overstayed his welcome, so to speak?

LD came to the scene in 2001 at the age of 18.  From 2004 to 2014, for 11 years, he was the best player in the world.  From 2004 to 2008 he was ranked #1.  From 2009 to 2014 he was no better than #2 but still considered the favorite: he wasn’t ranked higher simply because he skipped many events, and when he entered any event he was still expected to win, which he did most of the time.  His final tournament as the undisputed best player in the world was 2014 Asian Games singles, when he beat LCW in the semi and Chen Long in the final.  But in 2015 and 2016 the best player became Chen Long.  In 2017 Axelsen and LCW.  Since late 2018 Kento Momota.  In 2015 and 2016 LD was still competitive but no longer the best.  After 2017 losses were common, with more and more people beating LD.  His last title at 2019 Malaysia Open was luck, as Chou Tien-chen gave the match away. 

What happened?  Well, everybody gets old.  More precisely, my 6/9/2015 blog pointed to the ultimate role of athleticism in sports.  The thesis is that among top players, differences in skill sets are minimal, so only how athletic, strong and fit, one is over a certain period of time matters.  Anybody seeing LD play instantly recognizes he was also one of the best athletes of all time.  He started from a much higher level than the rest of the field, that in 2008 Olympics he won all matches 2:0 without anybody challenging him in any way in any game, including the resounding final.  Analogous to a 400 meter race: LD rushed to a big lead by the first 100 m and then just strolled all by himself for the rest 300 m.  

But from 2010 on LD often needed 3 sets to win.  For example, in the 2012 Olympics he beat Sho Sasaki, a second-tier player, in 3, and LCW in 3 in the final.  In the 2014 Asian Games, he beat LCW and CL all in 3 sets.  Like he was edging out only in the last 50 m or 10 m in a 400 m race.  More and more people were giving LD trouble even when they still lost.  One could argue others were getting better.  But the main reason is LD slipping, relatively, because one or two players improving is feasible, but all people can’t be improving at the same time.  Since physical ability is supreme, not unique in LD’s case, any drop due to aging would be amplified, especially when LD came down from such a height.  After 2015 and 2017, with his athleticism and stamina further deteriorating, LD finally lost the ability to win long matches, and more players, the younger ones, were beating him routinely.  But why was LD no longer the best after the age of 31, when Federer, Nadal, and Djokovic are still going strong?  My 12/31/2019 blog explains this a lot.  

It is fortunate to see and have LD playing for so long.  Fighting to the end and losing is sad, but winning and losing are always part of life.  We might never see anything like this ever again.