The biggest news in the young 2020 is undoubtedly the Wuhan coV,
which started in late Dec, 2019, according to hospital records and local media
reports at the time. Within 2-3 weeks
(early 2020), the new coV virus had been isolated and sequenced, allowing definitive
identification of patients and a better understanding of the extent of infection. Since mid-late January 2020, drastic
measures have been imposed on the Wuhan city, then most of the Hubei
province. Commonly referring to “lockdown”
in the media, these measures include suspension of public transportation within
the cities, and no train and flight services into and out of the cities,
although trains passing by may still be running, and private cars can still more or
less move. Most other places in China
have later enacted traveling or visiting restrictions of their own.
All these are serious overreactions, based on what we know
about the disease and other diseases.
First, what we know. As of Jan 27, there are approximately 2900 confirmed
cases, 5800 suspected cases, over 60000 quarantined, and 81 deaths. Infections and deaths will increase further,
but infections are much easier to underestimate, so the mortality rate will likely drop to or below 1% when the dust
settles. Most deaths are the elderly with additional health
conditions, with children less likely to be infected, and young adults typically
having few or only mild symptoms. Much has
been said about how easily the new coV spreads, but this is hard to assess for
two reasons, not mutually exclusive. One
is that, based on current quarantine-release data and media reports, family
members much more often not are not sickened by a patient. The other is how to define a
transmission. If you get the virus into
your lung/system, but you have no symptoms, does it count as an infection, a successful
infection, or anything? Are you able to
pass the virus to others? PCR detects coV, but it doesn’t tell you physiology. As for many viruses, like Zika, most infected
individuals have no symptoms and don’t even know they are infected. There are obviously unanswered questions
here, but the overall picture is emerging: the coV is not that THAT transmissible
and not THAT dangerous.
Next, what those drastic measures like lockdown do to the pubic health
system in Wuhan, in Hubei, and in the rest of China. The most obvious and natural reaction is panicking. Many people are rushing out of Wuhan, and residents
elsewhere are looking at people from Wuhan and Hubei suspiciously, even though at
least 99% of them are absolutely not infected.
Then in Wuhan, hospitals are flooded with people with a tiny bit of fever
or coughing, instantly overwhelming the healthcare system. If you didn’t have the coV before, you are now
much more likely to get it from the hospitals.
Because of so many “patients” jamming the hospitals, the real coV patients
will actually receive less attention, maybe partly explaining the recent spikes
in coV deaths. If you have other health
problems, like heart attack, cancer, GI issues, etc, since the public transport
is down, taxis are fewer (drivers are afraid too), most ambulances are for coV
now, your local hospitals have been converted for coV treatment, leading to a
longer trip, you will have less care and will be adversely affected. In other words, these drastic measures, while
will probably reduce coV infections and deaths, will likely increase deaths due
to other causes, including depression.
And I have yet to count the major disruption in economic and social
activities, which have their own vast monetary and life values.
Then why did the governments instigate such restrictions? The officials may truly believe they are
doing the right thing, but the most underlying reason is panicking, and facing
immerse pressure from the internet and social media in China. It is better to do something big, so that nobody
can fault me for not taking coV seriously.
Whether it will work, or whether it will do more harm than good, nobody in
the social media understands. Scientists
may analyze the data months later and find it unhelpful, but everybody else will
forget about it by then.
During the winter season, most people will have common cold
and flu, from viruses (including other, “old” coVs), have a fever and cough,
and recover in a few days. Old people
are also the most susceptible. Even if you are not infected, if you hear so much about coV, you may feel sick as well. When you
get sick, the best treatment is to rest in a quiet environment, and relax. But if it is noisy outside, because of all the
commotion from the new coV, and with the mental pressure from the non-stopping internet
and TV coverage of the epidemic, your recovery will be hampered. The death rate from common cold and flu may
be a bit lower than the new coV, but tens of thousands of people die from them in
China every year. For the new coV, while
hard to count an infection at the moment (see above), it seems implausible to be
more deadly than SARS (800 deaths) in 2003.
In fact, most measures adopted in China right now are to
identify individuals with a fever, especially from the Hubei province, and quarantine
them and those people in contact with them.
But since most people, Hebei or not, definitively don’t have coV, and
many people, Hebei or not, have common cold or flu, vast energy, resource, and
mentality is being wasted, which inevitably reduces attention to other, real
problems. I can even imagine a scenario
that someone has both coV and common cold infections. PCR identifies coV, but his symptoms actually
arise from the common cold (because coV is not intrinsically THAT dangerous,
see above). We will give him a separate
room in a hospital for 3 weeks, many tests, expensive machines and drugs, and
keep his 20 family and friends in a “hotel” for 15 days. All is to just make us feel good and
safe. The best outcome is he recovers,
but the likely outcome is he and family and friends will get unnecessarily anxious
and depressed, and the worst outcome is somebody else who really needs better
care does not. The current situation in China is that the Chinese officials seem
unknowingly trying to fight a war against the common cold and flu, not just coV. This is a fool’s errand. This is beyond current human knowledge and
ability. It will fail.
But what really should be done? Well, first lift the lockdown, and tell the public
be careful, but not fearful. Allow
public transportation: you will see fewer passengers, and chance of getting
infected is very low. Allow one-time masks to be
freely distributed at public transport stations. Advertising to turn on the heat indoor. Most Chinese in the south don’t like heating in
the winter at home because they prefer to have outside air and to save money,
but this tradition and notion must change: it is cheaper to spend on your
electricity at home than getting sick, and there are other ways to circulate air. I have no problem with quarantine and treatment
measures, except not to cast a too wider net than necessary. Regardless, eventually the Chinese governments
will have to loosen the criteria to lift the lockdown and declare the
end of Wuhan coV saga.
Lastly, hyperbole happened everywhere, not just in
China. A glaring example is https://republicanfreedom.com/2020/01/26/thermonuclear-pandemic-level-bad-harvard-epidemiologist-warns-viral-outbreak-might-get-a-lot-worse/. It is so silly that it hurts your eyes to read. It even quoted some experts, but there are scientists
who don’t think HIV causes AIDS, so what does it mean? Following
this line of thought, it is curious that expert who have spoken so far publicly
are mostly medical doctors and PhD scientists analyzing the coV, and their comments
are narrowly focused. Few “prominent”
biologists have said anything, especially about the drastic measures in
China. China’s Rao Yi, who has been
outspoken on many topics, only said, before the widespread lockdown, that it is
a new virus, so everything is possible. Words
that are true, but also useless. I am venturing
to say that most basic biological scientists share my concerns but are not talking
because they don’t want to seem aloof in face of a new public health crisis and
criticize the draconian measures, which have good intentions and satisfy
popular instincts but will ultimately fail the cost vs benefit test.
Regarding the new coV, my hunch is that it will stay with humans for a while as an annoyance, just like other coVs that cause the common cold, especially if it is found to be as infectious. But unlike the flu, coVs are likely better targets for antiviral drugs and vaccines, so the threat will be better contained later, definitely not the thermonuclear level.
Regarding the new coV, my hunch is that it will stay with humans for a while as an annoyance, just like other coVs that cause the common cold, especially if it is found to be as infectious. But unlike the flu, coVs are likely better targets for antiviral drugs and vaccines, so the threat will be better contained later, definitely not the thermonuclear level.
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.